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Dmt-2fluoro-da(bz) amidite
CAS No. 136834-22-5
Dmt-2fluoro-da(bz) amidite( —— )
Catalog No. M34881 CAS No. 136834-22-5
Dmt-2'fluoro-da(bz) amidite is a 2'-deoxy-2'-fluoro-phosphorothioate oligonucleotide with high affinity and specificity for RNA targets and serves as an intermediate in the synthesis of 5'-DMT-3'-phosphoramidite, an antisense compound resistant to nuclease.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 500MG | 40 | In Stock |
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| 1G | 53 | In Stock |
|
Biological Information
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Product NameDmt-2fluoro-da(bz) amidite
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NoteResearch use only, not for human use.
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Brief DescriptionDmt-2'fluoro-da(bz) amidite is a 2'-deoxy-2'-fluoro-phosphorothioate oligonucleotide with high affinity and specificity for RNA targets and serves as an intermediate in the synthesis of 5'-DMT-3'-phosphoramidite, an antisense compound resistant to nuclease.
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DescriptionDmt-2'fluoro-da(bz) amidite, an uniformly modified 2'-deoxy-2'-fluoro phosphorothioate oligonucleotide, is a nuclease-resistant antisense compound with high affinity and specificity for RNA targets. Dmt-2'fluoro-da(bz) amidite is also an intermediate for 5’-DMT-3’-phosphoramidite synthesis.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetDNA/RNA Synthesis
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RecptorDNA/RNA Synthesis
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Research Area——
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Indication——
Chemical Information
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CAS Number136834-22-5
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Formula Weight875.92
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Molecular FormulaC47H51FN7O7P
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (114.17 mM; Ultrasonic )
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SMILESCOc1ccc(cc1)C(OC[C@H]1O[C@H]([C@H](F)[C@@H]1OP(OCCC#N)N(C(C)C)C(C)C)n1cnc2c(NC(=O)c3ccccc3)ncnc12)(c1ccccc1)c1ccc(OC)cc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Gallium maltolate
Gallium maltolate is a ribonucleoside-diphosphate reductase inhibitor.
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Blasticidin S HCl
Blasticidin S HCl is a nucleoside antibiotic isolated from Stretomyces girseochromogenes and acts as a DNA and protein synthesis inhibitor.
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HALOFUGINONE LACTATE
HALOFUGINONE LACTATE is a halogenated derivative of febrifugine, a natural quinazolinone-containing compound found in the Chinese herb D. febrifuga.Halofuginone inhibits prolyl-tRNA synthetase in an ATP-dependent manner with a Ki of 18.3 nM.?Halofuginone is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activityhalofuginone (HF), a widely studied derivative of febrifugine, inhibits the development of T(H)17-driven autoimmunity in a mouse model of multiple sclerosis by activating the amino acid response (AAR) pathway.?HF binds glutamyl-prolyl-tRNA synthetase (EPRS), inhibiting prolyl-tRNA synthetase activity;?this inhibition is reversed by the addition of exogenous proline or EPRS.
