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Home - Products - Cell Cycle/DNA Damage - DNA/RNA Synthesis - Dmt-2fluoro-da(bz) amidite

Dmt-2fluoro-da(bz) amidite

CAS No. 136834-22-5

Dmt-2fluoro-da(bz) amidite( —— )

Catalog No. M34881 CAS No. 136834-22-5

Dmt-2'fluoro-da(bz) amidite is a 2'-deoxy-2'-fluoro-phosphorothioate oligonucleotide with high affinity and specificity for RNA targets and serves as an intermediate in the synthesis of 5'-DMT-3'-phosphoramidite, an antisense compound resistant to nuclease.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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1G 53 In Stock
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Biological Information

  • Product Name
    Dmt-2fluoro-da(bz) amidite
  • Note
    Research use only, not for human use.
  • Brief Description
    Dmt-2'fluoro-da(bz) amidite is a 2'-deoxy-2'-fluoro-phosphorothioate oligonucleotide with high affinity and specificity for RNA targets and serves as an intermediate in the synthesis of 5'-DMT-3'-phosphoramidite, an antisense compound resistant to nuclease.
  • Description
    Dmt-2'fluoro-da(bz) amidite, an uniformly modified 2'-deoxy-2'-fluoro phosphorothioate oligonucleotide, is a nuclease-resistant antisense compound with high affinity and specificity for RNA targets. Dmt-2'fluoro-da(bz) amidite is also an intermediate for 5’-DMT-3’-phosphoramidite synthesis.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    DNA/RNA Synthesis
  • Recptor
    DNA/RNA Synthesis
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    136834-22-5
  • Formula Weight
    875.92
  • Molecular Formula
    C47H51FN7O7P
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (114.17 mM; Ultrasonic )
  • SMILES
    COc1ccc(cc1)C(OC[C@H]1O[C@H]([C@H](F)[C@@H]1OP(OCCC#N)N(C(C)C)C(C)C)n1cnc2c(NC(=O)c3ccccc3)ncnc12)(c1ccccc1)c1ccc(OC)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kawasaki AM, et, al. Uniformly modified 2'-deoxy-2'-fluoro phosphorothioate oligonucleotides as nuclease-resistant antisense compounds with high affinity and specificity for RNA targets. J Med Chem. 1993 Apr 2;36(7):831-41.?
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